第11回BAS合同セミナー 招待講演 

スピーカー:羽田明子教授 Prof. Akiko Hata
所属:UCSF, Dept. of CVRI
演題:Regulation of Vascular Cell Phenotype by the TGFbeta family of signaling pathway

講演要旨The transforming growth factor beta (TGFbeta) super-family of growth factors, including bone morphogenetic proteins (BMPs) and TGFbetas, orchestrates fundamental biological processes in development and in the homeostasis of adult tissues, including the vasculature. We show that induction of a contractile phenotype in vascular smooth muscle cells (VSMCs) by TGFbeta and BMPs is mediated by miR-21. Surprisingly, TGFbeta/BMP signaling promotes a rapid increase in expression of mature miR-21 through a post-transcriptional step, promoting the processing of primary transcripts of miR-21 (pri-miR-21) into precursor miR-21 (pre-miR-21) by the Drosha complex. Smad proteins, the signal transducers of the TGFbeta family of growth factors, are required for ligand-induced upregulation of pre-miR-21 and mature miR-21. We will discuss a potential mechanism of regulation of miRNA biogenesis by the BMP/TGFbeta signaling pathway.
ベイエリアセミナーとは
Japanese San Francisco Bay Area Seminar は生物学・医学に関するセミナー開催を中心的な活動として研究者支援を行っている非営利団体です。

 
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